PowerPlay is a multiplier option used in the US multi-state lottery jackpot game Powerball.

The Powerball PowerPlay is optional. Powerball tickets normally cost $1 each; activating PowerPlay raises the price to $2 for any player selection (five regular numbers plus the red "Powerball"; whether the player selects the numbers themself and/or has the numbers "quick-picked") where the PowerPlay is activated. Before each Powerball drawing, a multiplier (2x, 3x, 4x, or 5x; during a yearly promotion, one of the 5x "spaces" is replaced by "10x") is randomly chosen. If a player wins a Powerball prize (excluding the jackpot), and PowerPlay was activated for that game, the multiplier applies to that game. For example, matching only the red "Powerball" usually wins $3; but, if that selection had PowerPlay activated, and the multiplier is 5, the prize is $15.

Usually, the maximum possible PowerPlay prize is $1 million (cash), if a player matches all five regular balls ($200,000; missing only the red Powerball number) and the PowerPlay is 5. (When the 10x space is in play, a non-jackpot win of $2 million cash is possible; that promotion always guarantees at least one Powerball drawing with a PowerPlay of 10x, extending the promotion if necessary.)

With Florida joining Powerball in January 2009, becoming MUSL's most-populous member, Powerball changed its matrices to create larger jackpots. The PowerPlay multipliers did not change, except for second prize; a PowerPlay ticket matching all five white balls (missing only the red ball) wins, under normal conditions, $1 million cash, as the PowerPlay is automatically 5x for second prize (randomly 2x through 5x for the seven lower levels). Another change is that, in place of the wheel, the PowerPlay multiplier is drawn using a random number generator, or RNG. (The six winning numbers are drawn using numbered balls from two drawing machines.)